Optimizatiom of Enantioseparations in High Performance Liquid Chromatography using Polysaccharide Based Chiral Selectors

Author: Giorgi Jibuti
Co-authors: Bezhan Chankvetadze, Tivadar Farkas
Keywords: Chirality, Enantiomers, Optimization
Annotation:

In this work, the ways are described for optimization of HPLC separations of chiral compounds. In particular, following approaches are described: 1) Optimizing mobile phase by using normal phase, polar-organic phase, reverse phase and minor additives in mobile phase. [2] 2) Optimizing inert carrier for coating CS – by optimizing size and morphology of carrier particles, using various types of superficially porous silica gel particles to prepare CS [3] 3) Optimizing instrumentation – by reducing dead volume by using fused silica capillaries, bypassing several areas in flowpath and using of the high-speed detection.