The role of early postnatal feeding of rats with flavonoids from Saperavi on characteristics of epileptiform activity induced by electrical stimulation of the CA1 field of the hippocampus

Author: Butsiko Chkhartishvili
Co-authors: M. Chikovani, T. Qurasbediani, B. Partsvania, R. Bukia A. Chakhnakia, N. Doreulee
Keywords: Flavonoids, Saperavi, hippocampus, epileptiform discharges.
Annotation:

In recent years the new treatment strategies for neurodegenerative disorders focuses on flavonoids - plant antioxidants, which are characterized by anti-allergic, neuroprotective activity. flavonoids traverse the blood-brain barrier and are able to localize in the brain, with significantly higher levels in hippocampus and cortex, suggesting that they are candidates for direct neuroprotective and neuromodulative actions[2,3]. The hippocampus plays an important role in a learning/memory processes and it is also a common focus site in epilepsy[1]. Our previous experiments showed that early postnatal supplementation with flavonoids from Saperavi grapes have beneficial effects on the hippocampal-related learning mechanisms and the ability to increase the number of BrdU positive cells in the dentatus gyrus of the rats. Flavonoids from saperavi also effectively protect the rat hippocampus from kainic acid – induced neuronal injury and memory distruption associated with it. The aim of the present work was to investigate the effects of early life exposure to flavonoids from saperavy (P7-P15, 25mg/kg per day) on the electrophysiological characteristics of the hippocampal neurons; on the threshold of epileptiform discharges and the properties of high-frequency activity (duration, amplitude envelope, and frequency spectrum). According to our preliminary data early postnatal feeding with flavonoids from Saperavi increases the threshold of electrically induced epileptiform discharges, inhibits spontaneous hippocampal seizures in a control animals, as well as in a kainic acid rat model of epilepsy. The work is supported by Rustaveli foundation, grant FR/617/7-270/13.

Lecture files:

საფერავის ფლავონოიდებით ვირთაგვების ადრეული პოსტნატალური კვების გავლენა ჰიპოკამპის CA1 ველში ელექტრული სტიმულაციით გამოწვეული ეპილეფტიფორმული აქტივობის მახასიათებლებზე [ka]
The role of early postnatal feeding of rats with flavonoids from Saperavi on characteristics of epileptiform activity induced by electrical stimulation of CA1 field of hippocampus [en]